PROBLEM 1:

SHINGLES IS A THREAT TO NEARLY EVERYONE

99% of adults ≥50 years old
are infected with the virus
that causes shingles1
  • After primary exposure, the varicella zoster virus establishes residency in the dorsal and cranial nerve ganglia2-4
  • The body builds immunity that keeps the virus contained5
  • Over the course of an individual’s lifetime, the dormant virus can reemerge6
  • The virus reactivates in 1 out of 3 people and causes shingles5

As immunity against the virus decreases with age, the risk of reactivation increases7

99% of adults ≥50 years old
are infected with the virus
that causes shingles1
  • After primary exposure, the virus establishes residency in the dorsal and cranial nerve ganglia2-4
  • The body builds immunity that keeps the virus contained5
  • Over the course of an individual’s lifetime, the dormant virus can reemerge6
  • The virus reactivates in approximately 1 out of 3 people and causes shingles5

As immunity against the virus decreases with age, the risk of reactivation increases7

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References: 1. Kilgore PE, Kruszon-Moran D, Seward JF, et al. Varicella in Americans from NHANES III: implications for control through routine immunization. J Med Virol. 2003;70(suppl 1):S111-S118. 2. Mahalingham R, Wellish M, Wolf W, et al. Latent varicella-zoster viral DNA in human trigeminal and thoracic ganglia. N Engl J Med. 1990;323(10):627-631. 3. Lungu O, Annunziato PW, Gershon A, et al. Reactivated and latent varicella-zoster virus in human dorsal root ganglia. Proc Natl Acad Sci USA. 1995;92(24):10980-10984. 4. Furuta Y, Takasu T, Fukuda S, et al. Detection of varicella-zoster virus DNA in human geniculate ganglia by polymerase chain reaction. J Infect Dis. 1992;166(5):1157-1159. 5. Centers for Disease Control and Prevention. Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2008;57(RR-5):1-30. 6. Hope-Simpson RE. The nature of herpes zoster: a long-term study and a new hypothesis. Proc R Soc Med. 1965;58(1):9-20. 7. Weinberg A, Lazar AA, Zerbe GO, et al. Influence of age and nature of primary infection on varicella-zoster virus—specific cell-mediated immune responses. J Infect Dis. 2010;201(7):1024-1030.

821868R0 October 2017