PROBLEM 2:

AGE-RELATED DECLINE IN VZV IMMUNITY IS A DOMINANT DRIVER OF SHINGLES1-3

CHICKENPOX

EXPOSURE TO VZV
INDUCES IMMUNITY

THIS IMMUNITY
DECLINES OVER TIME

RESULTING IN
AN INCREASED
RISK OF
SHINGLES

Conceptual depiction of disease state. An exact immunity level at which shingles occurs has not been established.
Adapted from Kimberlin DW, et al. N Engl J Med. 2007.

VZV=varicella zoster virus.

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Conceptual depiction of disease state. An exact immunity level under which shingles occurs has not been established. Adapted from Kimberlin DW, et al. N Engl J Med. 2007.

VZV=varicella zoster virus.

References: 1. Hope-Simpson RE. The nature of herpes zoster: a long-term study and a new hypothesis. Proc R Soc Med. 1965;58(1):9-20. 2. Kimberlin DW, Whitley RJ. Varicella–zoster vaccine for the prevention of herpes zoster. N Engl J Med. 2007;356(13):1338-1343. 3. Centers for Disease Control and Prevention. Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2008;57(RR-5):1-30.

821868R0 October 2017