College Impact: Meningitis 101
The potential impact of meningococcal disease on college students

Although meningococcal disease is rare,4 rare happens. By educating yourself on how meningococcal disease is a potential campus-wide threat and how serogroup B may be overlooked,4 you'll see why it's worth helping to protect your campus against meningococcal disease, including serogroup B.

A potential campus-wide threat

Regardless of serogroup, meningococcal disease is transmitted through respiratory droplet secretions, such as saliva. This puts many college students at an increased risk of contracting meningococcal disease due to their age-related behaviors.8
 
Some of the behaviors known to increase the risk of spreading the disease include8,9,12
Coughing/Sneezing
Smoking
Kissing
Sharing eating utensils, drinks, and smoking devices
Living in close quarters

How close has meningococcal disease come to your campus?

According to the National Meningitis Association, from 2013-2017, meningococcal disease has been reported on over 50 US college campuses.13
Cases and outbreaks on college campuses, 2013-201713
Map adapted from National Meningitis Association (NMA). Data based on media reports and cases reported directly to the NMA. Additional cases that were not featured in the news may be missing.
From 2011 through March 2019, meningitis B caused all US college meningococcal outbreaks, which involved 13 campuses, 50 cases, and 2 deaths among an at-risk population of approximately 253,000 students.14

Prevalence of MenB Ages 16-23

(n=188)
Although CDC data (as previously presented) showed that 1/3 of all US meningococcal cases from 2007-2016 in patients <1 to ≥65 years of age were MenB,10 the prevalence of MenB disease was even higher in adolescents and young adults 16-23 years of age, with MenB accounting for >60% of all US meningococcal cases in this age group (N=188).15
*Includes other, nongroupable, and unknown serogroups.
Furthermore, CDC data from 2014-2016 showed a peak in the incidence of MenB in adolescents and young adults between 18-20 years of age, regardless of college status.11
Source: National Notifiable Diseases Surveillance System (NNDSS) data with additional serogroup data from Active Bacterial Core surveillance (ABCs) and state health departments. Unknown serogroup and other serogroups excluded.
While meningococcal disease is uncommon, studies have shown that between 2014-2017, the relative risk of contracting MenB was 3.5 to 5 times higher in college students aged 18-24 years compared with peers not attending college.14,16,*,†
*0.17 cases in college students vs 0.05 cases in peers not attending college per 100,000 population in 2014-2016
0.22 cases in college students vs 0.04 cases in peers not attending college per 100,000 population in 2015-2017

Proactive about prevention

Which type of college/university are you associated with?
Public
Private
For the most up-to-date vaccine pre-matriculation recommendations and requirements for meningococcal disease, please contact your state departments of health or the institution directly in inquiry or check its website.
Despite most colleges having vaccination requirements for MenACWY, only a small percentage have implemented vaccination requirements for MenB.17,18
REQUIRE
MenB vaccination
before enrollment‡,§
RECOMMEND
MenB vaccination
before enrollment
Are you helping to protect your campus against MenB?
Don’t ignore the impact MenB could have on your campus
For more information on meningococcal disease and the potential dangers it poses on your campus, you can visit the Centers for Disease Control and Prevention website.
See the impact meningococcal disease has had on real people
Vaccination may not protect all recipients.
The people in these videos are advocates for meningococcal disease vaccination. Some were compensated by GSK for their participation. These videos are personal experiences; other people's experiences with meningococcal disease may be different.

References: 1. Meningococcal vaccines for preteens, teens. Centers for Disease Control and Prevention website. http://www.cdc.gov/features/meningococcal/. Updated April 18, 2016. Accessed July 12, 2018. 2. Meningococcal disease. In: Hamborsky J, Kroger A, Wolfe S, eds. Epidemiology and Prevention of Vaccine-Preventable Diseases. 13th ed. Washington, DC: Public Health Foundation; 2015;261-278. http://www.cdc.gov/vaccines/pubs/pinkbook/mening.html. Accessed July 12, 2018. 3. Thompson MJ, Ninis N, Perera R, et al. Clinical recognition of meningococcal disease in children and adolescents. Lancet. 2006;367(9508):397-403. 4. Pelton SI. Meningococcal disease awareness: clinical and epidemiological factors affecting prevention and management in adolescents. J Adolesc Health. 2010;46:S9-S15. 5. Slack R, Hawkins KC, Gilhooley L, Addison GM, Lewis MA, Webb NJA. Long-term outcome of meningococcal sepsis-associated acute renal failure. Pediatr Crit Care Med. 2005;6(4):477-479. 6. Vyse A, Anonychuk A, Jäkel A, et al. The burden and impact of severe and long-term sequelae of meningococcal disease. Expert Rev Anti Infect Ther. 2013;11(6):597-604. 7. Cohn AC, MacNeil JR, Clark TA, et al. Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2013;62(RR-2):1-28. 8. MacNeil J, Cohn A. Meningococcal disease. In: Roush SW, Baldy LM, eds. Manual for the Surveillance of Vaccine-Preventable Diseases. 6th ed. http://www.cdc.gov/vaccines/pubs/surv-manual/chpt08-mening.html. Updated April 1, 2014. Accessed July 12, 2018. 9. Meningococcal disease: causes and transmission. Centers for Disease Control and Prevention website. http://www.cdc.gov/meningococcal/about/causes-transmission.html. Updated June 11, 2015. Accessed July 12, 2018. 10. Centers for Disease Control and Prevention. Active bacterial core surveillance (ABCs). Neisseria meningitidis, 2005-2014. Centers for Disease Control and Prevention website. http://www.cdc.gov/abcs/reports-findings/surv-reports.html. Accessed July 12, 2018. 11. Meyer S. Epidemiology of meningococcal disease among college students—United States, 2014-2016. https://stacks.cdc.gov/view/cdc/59918. Presented at the Advisory Committee on Immunization Practices meeting; February 22, 2018. Accessed June 25, 2019. 12. Mayo Clinic. Meningitis. https://www.mayoclinic.org/diseases-conditions/meningitis/symptoms-causes/syc-20350508. Accessed August 7, 2019. 13. Meningococcal Disease on U.S. College Campuses, 2013-2019. National Meningitis Association. www.nmaus.org/wp-content/uploads/2019/04/Alembic_NMA_Map_r28.pdf. Updated April 2019. Accessed June 5, 2019. 14. Marshall GS, Dempsey AF, Srivastava, Isturiz RE. US college students are at increased risk for serogroup B meningococcal disease. JPIDS. 2019:1-4. 15. Enhanced Meningococcal Disease Surveillance Reports, 2015-2017. Centers for Disease Control and Prevention website. www.cdc.gov/meningococcal/surveillance/index.html#enhanced-reports. Accessed June 5, 2019. 16. Mbaeyi SA, Joseph SJ, Blain A, et al. Meningococcal Disease Among College-Aged Young Adults: 2014–2016. Pediatrics. 2019;143(1):1-8. 17. Data on file, GSK. 18. Meningococcal ACWY prevention mandates for colleges and universities. Immunization Action Coalition website. www.immunize.org/laws/menin.asp. Updated November 11, 2018. Accessed June 5, 2019.

BEXWCNT190014 September 2019